Article: PSA before age 50 predicts long-term risk of prostate ca: findings might affect screening guidelines.(News)

ANAHEIM, CALIF. -- A single measurement of prostate-specific antigen in men aged 44-50 was a powerful predictor of advanced prostate cancer later in life, researchers reported at the annual meeting of the American Urological Association.

For a man in his mid- to late 40s, even a small elevation in total PSA markedly increased the risk of later being diagnosed with a metastatic or clinical stage T-III or more advanced prostate cancer, said Andrew J. Vickers, Ph.D., of Memorial Sloan-Kettering Cancer Center in New York.

"All of the prostate cancers in this study would affect the quality and quantity of a man's life," he added during an interview.

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