Article: Expression profiling with RNA from formalin-fixed, paraffin-embedded material.(Technical advance)(messenger ribonucleic acid)

Authors: Andrea Oberli (equal contributor) [1]; Vlad Popovici (equal contributor) [2]; Mauro Delorenzi [2,3]; Anna Baltzer [1]; Janine Antonov [1]; Sybille Matthey [1]; Stefan Aebi [1]; Hans J örg Altermatt [4]; Rolf Jaggi (corresponding author) [1]

Background

Breast cancer has been widely studied in the past and molecular characterization has increased the understanding of biological pathways that are altered during neoplastic transformation of cells [1, 2, 3, 4]. However, the findings based on molecular profiling have not yet altered diagnosis, and decisions about treatment still rely mostly on histopathological and immunohistochemical ...

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