Magazine article from our research archive:
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The human kinome--Invitrogen Corp. poster caption.
- Article from:
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Chemistry International
- Article date:
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March 1, 2008
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Copyright informationCOPYRIGHT 2008 International Union of Pure and Applied Chemistry. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Phosphorylation by protein kinases represents a central theme within signal transduction. Since the description of reversible protein phosphorylation influencing protein activity by Fischer and Krebs in 1955, protein kinases have been shown to play central roles in the regulation of most critical cellular processes. Given the importance of the coordinated action of these enzymes, it is not surprising that misregulation of protein kinases is a cause or consequence of many diseases.
[ILLUSTRATION OMITTED]
This circular diagram represents an artistic interpretation of the phylogenetic relationships between all members of the human kinase family. Our bioinformatics ...
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The Arabidopsis CDPK-SnRK Superfamily of protein kinases
Plant Physiology;
June 1, 2003 ;
Hrabak, Estelle M; Chan, Catherine W M; Gribskov, Michael; Harper, Jeffrey F; Et al;
787 words
......seven types of serine-threonine protein kinases: calcium-dependent protein kinase...kinases (PEPRKs), calmodulin-dependent protein kinases (CaMKs), calcium and calmodulin-dependent protein kinases (CCaMKs), and SnRKs. Within this...
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Systematic trans-genomic comparison of protein kinases between arabidopsis...
Plant Physiology;
August 1, 2003 ;
Wang, Degeng; Harper, Jeffrey F; Gribskov, Michael;
787 words
......report a systematic comparison of the protein kinases of yeast (119 kinases) and a reference...clustering approach, the complete set of protein kinases from both species were clustered...genes that are unique to a species. Protein kinases are good targets for such study because...
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Carna Biosciences Signs Distribution Agreements to Expand Businesses in...
PR Newswire Europe;
August 4, 2006 ;
362 words
......Bio-Connect exclusive rights to sell protein kinases in Germany, the United Kingdom, France...KinaseDetect exclusive rights to sell protein kinases in the Scandinavian countries (Denmark...succeeded in producing more than 240 protein kinases. Pure and highly active kinases are...
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Differential Activation of the Rice Sucrose Nonfermenting1-Related Protein...
Plant Cell;
May 1, 2004 ;
Kobayashi, Yuhko; Yamamoto, Shuhei; Minami, Hideyuki; Kagaya, Yasuaki; Hattori, Tsukaho;
787 words
......date, a large number of sequences of protein kinases that belong to the sucrose nonfermenting1-relat...signaling. We identified 10 SnRK2 protein kinases encoded by the rice (Oryza sativa...phosphoinositides and enzymes that generate them, protein kinases, and phosphatases (Munnik et ...
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OriGene Technologies Awarded NHGRI Grant to Develop a Validated shRNA...
PR Newswire;
June 30, 2005 ;
436 words
......com/cgi-bin/prnh/20030815/ORILOGO ) Protein kinases mediate most of the cellular signal...critical roles in cancer development, protein kinases are also implicated in wide range...system and central nervous system. Protein kinases have emerged as one of the best targets...
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Nanogen Reports Progress in Development of Electronic Technology For...
PR Newswire;
March 20, 2001 ;
787 words
......HTS) of drug candidates acting on protein kinases and potentially a wide variety of...for a wide range of enzyme targets. Protein kinases are widely used by drug development...known that there are approximately 800 protein kinases in the human genome. Furthermore...
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Protein Kinases & Phosphatases Conference to Feature Latest Industry &...
PR Newswire;
February 13, 2002 ;
392 words
......follow-up to the highly successful Protein Kinases in Drug Discovery & Development...their latest research in the field. Protein kinases & phosphatases are two of the...neurodegeneration, and inflammation, protein kinases & phosphatases could potentially...
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The Rice Kinase Database. A Phylogenomic Database for the Rice Kinome1[OA]
Plant Physiology;
February 1, 2007 ;
Dardick, Christopher; Chen, Johann; Richter, Todd; Ouyang, Shu; Ronald, Pamela;
787 words
......Oryza saliva) genome contains 1,429 protein kinases, the vast majority of which have unknown...redundancy poses enormous challenges is protein kinases. Kinases comprise a highly conserved...similarity found between even diverse protein kinases and the ability to generate robust...
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New Developments in Protein Kinases & Phosphotases the Focus of Conference...
PR Newswire;
November 8, 2001 ;
333 words
......iteration of the highly successful Protein Kinases in Drug Discovery & Development...announces Strategic Research Institute. Protein Kinases & Phosphotases in Drug Discovery...The keynote presentation, entitled, Protein Kinases and Phosphotases in the Age of Genomics...
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Protein Kinases & Phosphotases in Drug Discovery & Development Conference...
PR Newswire;
November 1, 2001 ;
293 words
......follow-up to the highly successful Protein Kinases in Drug Discovery & Development...announces Strategic Research Institute. Protein Kinases & Phosphotases in Drug Discovery...The keynote presentation, entitled, Protein Kinases and Phosphotases in the Age of Genomics...
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Protein Kinases & Phosphotases in Drug Discovery & Development Conference...
PR Newswire;
October 19, 2001 ;
289 words
......follow-up to the highly successful Protein Kinases in Drug Discovery & Development...announces Strategic Research Institute. Protein Kinases & Phosphotases in Drug Discovery...The keynote presentation, entitled, Protein Kinases and Phosphotases in the Age of Genomics...
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Massachusetts, New Jersey Inventors Develop Protein Kinases Inhibitor
US Fed News Service, Including US State News;
April 19, 2008 ;
206 words
......Young-Choon Moon of Belle Mead, N.J., have developed inhibitors of protein kinases. According to the U.S. Patent & Trademark Office: "The...present invention relates to compounds useful as inhibitors of protein kinases. The invention also provides pharmaceutically acceptable...
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ActivX Biosciences Launches Breakthrough Kinase Platform, KiNativ.
PR Newswire;
March 21, 2007 ;
495 words
......proprietary platform for the profiling of protein kinases and the analysis of kinase inhibitors...cgi-bin/prnh/20070320/LATU120LOGO ) Protein kinases comprise a large and medically important...task because there are over 500 human protein kinases and the structural similarities ...
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Osmotic stress induces rapid activation of a salicylic acid-induced...
Plant Cell;
January 1, 2000 ;
Miko-Iajczyk, Monika; Awotunde, Olubunmi S; Muszynska, Grazyna; Klessig, Daniel F; Dobrowolska, Grazyna;
787 words
......induced the rapid activation of two protein kinases that phosphorylate myelin basic protein...Kyriakis and Avruch, 1996). Numerous protein kinases with close sequence similarities to...TEY motif. In addition, some of the protein kinases involved in signaling appear to be...
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