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Article: Effect of orange juice on bioavailability of levofloxacin.
- Article from:
- Journal of Applied Research
- Article date:
- March 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 Therapeutic Solutions LLC. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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ABSTRACT
Objective: This work was designed to observe the effect of orange juice on the bioavailability of levofloxacin in healthy Bangladeshi volunteers.
Methods: A randomized 2-way crossover design was used with a washout period of 2 weeks. The volunteers ingested either 200 mL of orange juice or water 3 times a day for the first 3 days and 2 times a day on the fourth day. On the morning of Day 3, each subject was given a 250-mg levofloxacin tablet under fasting condition with 200 mL of orange juice or water. Thirteen blood samples were collected from each volunteer over a 24-hour period. Serum levofloxacin concentrations were determined by high ...