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Rules of tumor cell development and their application to biomarkers for ovarian cancer.

Purpose/Objectives: To apply the Hanahan and Weinberg conceptual framework for tumor development to the specific biomarkers observed or expressed in ovarian cancer.

Data Sources: Data-based publications, topical reviews, and book chapters.

Data Synthesis: Articles specific to ovarian cancer were reviewed to examine whether the six rules from the Hanahan and Weinberg conceptual framework were applicable to biomarkers of ovarian cancer. This approach allows for the application of a general framework for the development of solid tumors to the development of ovarian cancer.

Conclusions: The six rules for tumor cell development outlined in the Hanahan and Weinberg conceptual framework ...

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