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Statin myopathy: a brief review.(Disease/Disorder overview)
- Article from:
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AMAA Journal
- Article date:
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March 22, 2008
- Author:
- Thompson, Paul D.
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Copyright informationCOPYRIGHT 2008 American Running & Fitness Association. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Hydroxy-methyl-glutaryl (HMG) CoA reductase inhibitors or statins are the most effective medications for reducing low-density lipoprotein cholesterol (LDL-C) and cardiac events in both coronary artery disease (CAD) patients (1), (2) and in previously healthy subjects (3), (4). Statins are so effective that they are presently the most prescribed drugs in the United States and the world. Statins are well tolerated by the majority of patients, but can produce a variety of muscle problems ranging from myalgia, cramps, and weakness to rhabdomyolysis with acute renal failure and even death. Muscle symptoms are reported in 3-5% of patients enrolled in industry-sponsored clinical ...
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Fast and Slow Skeletal Troponin I in Serum from Patients with Various...
Clinical Chemistry;
June 1, 2005 ;
Simpson, Jeremy A; Labugger, Ralf; Collier, Christine; Brison, Robert J; Et al;
787 words
...Background: Detection of skeletal muscle injury is hampered by a lack of...Currently, the diagnosis of skeletal muscle injury (encompassing all types...protein) as a marker of skeletal muscle injury, just as its cardiac isoform...
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Gene therapy helps accelerate sportsmen's skeletal muscle injuries
The Hindustan Times;
June 5, 2006 ;
312 words
......therapy to accelerate muscle regeneration in experimental...approach for improving skeletal muscle healing, especially...sports-related injuries. Skeletal muscle injury is one of the most...the activity of the muscle-growth inhibitor...Four weeks after skeletal ...
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Carbon Monoxide may cut skeletal muscle injuries
The Hindustan Times;
June 9, 2008 ;
414 words
......it can significantly reduce skeletal muscle injury following limb peripheral...inflammation locally in the injured skeletal muscle and systemically in the blood...treated mice had less skeletal muscle injury compared to room air treated...
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Taking skeletal muscle to heart.
Science News;
November 19, 1988 ;
Weiss, Rick;
787 words
...Taking Skeletal Muscle to Heart Would you have your songs...increasingly are finding that skeletal muscle can be wrapped around a damaged...valuable assistance. Indeed, while skeletal muscle may never match the heart for...
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Bioimpedance analysis: Potential for measuring lower limb skeletal muscle...
JPEN, Journal of Parenteral and Enteral Nutrition;
March 1, 1999 ;
Nunez, Christopher; Gallagher, Dympna; Grammes, Jill; Baumgartner, Richard N; Et al;
787 words
......partially dependent on lower limb skeletal muscle mass. At present, both research and...clinical methods of evaluating lower limb skeletal muscle mass as a component of nutrition assessment...BIA system, and lower limb fat and skeletal muscle were estimated by dual-energy x-ray...
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A novel in vitro three-dimensional skeletal muscle model
In Vitro Cellular & Developmental Biology;
July 1, 2007 ;
Marquette, Michele L; Byerly, Diane; Sognier, Marguerite;
787 words
...Abstract A novel three-dimensional (3D) skeletal muscle model composed of C2C12 mouse myoblasts...Introduction Mature multinucleated skeletal muscle cells are formed and regenerated after...Such knowledge can also improve skeletal muscle tissue engineering approaches, current...
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Oral vitamin C reduces the injury to skeletal muscle caused by compartment...
Journal of Bone and Joint Surgery;
August 1, 2004 ;
Kearns, S R; Daly, A F; Sheehan, K; Murray, P; Et al;
787 words
......form of ischaemia of skeletal muscle which occurs despite...reperfusion-induced muscle injury. We have evaluated the...Compartment syndrome impaired skeletal muscle function and increased...microvascular hypoxia on muscle injury in compartment ...
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Chronic infusion of interleukin 1 induces hyperlactatemia and altered...
JPEN, Journal of Parenteral and Enteral Nutrition;
July 1, 1999 ;
Vary, Thomas C; O'Neill, Patrick; Cooney, Robert N; Maish, George III; Shumate, Margaret;
787 words
......hyperlactatemia and derangements in skeletal muscle and hepatic lactate metabolism was...in an elevated lactate content in skeletal muscle (p < .05) but not in liver. The...significantly (p < .05) in the skeletal muscle of animals infused with IL-1 compared...
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Muscle-derived CD45-SCA-1 + C-KIT- progenitor cells give rise to skeletal...
In Vitro Cellular & Developmental Biology;
October 1, 2002 ;
Royer, Cassandre L; Howell, Jonathan C; Morrison, Paul R; Srour, Edward F; Yoder, Mervin C;
787 words
......cell population isolated from murine skeletal muscle has recently been shown to differentiate...culture conditions, differentiate into skeletal muscle cells in vitro. Lower-extremity skeletal muscle tissue isolated from 3- to 4-wk-old...
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Morphology and molecular composition of sarcosplasmic reticulum surface...
Biophysical Journal;
June 1, 2002 ;
Felder, Edward; Protasi, Feliciano; Hirsch, Ronit; Franzini-Armstrong, Clara; Allen, Paul D;
787 words
......excitation-contraction coupling of skeletal muscle cells is initiated by the functional...charge movement restored in dysgenic skeletal muscle by injection of dihydropyridine receptor...isoforms in mature avian fast-twitch skeletal muscle. J. Biol. Chem. 265:14187-14194. Beam...
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Contribution of stem cells to skeletal muscle regeneration
Folia Histochemica et Cytobiologica;
April 1, 2006 ;
Kawiak, Jerzy; Brzóska, Edyta; Grabowska, Iwona; Hoser, Grazyna; Et al;
787 words
......mice Origin of stem cells for skeletal muscle Problems concerning the origin of skeletal muscle progenitor cells were recently...sclerotome and dermomyotome for skeletal muscle and skin, respectively. The...cells during embryogenesis. The skeletal muscle progenitor ...
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Dietary fatty acids influence the activity and metabolic control of...
The Journal of Nutrition;
November 1, 1997 ;
Power, Glen W; Newsholme, Eric A;
787 words
......Palmitoyltransferase I in Rat Heart and Skeletal Muscle' Glen W. Power23 and Eric A. Newsholme...inhibition by malonyl CoA in rat heart and skeletal muscle. The nutritional state of rats has...of mitochondrial CPT I in heart and skeletal muscle tissue than in the liver, a tissue...
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Skeletal Muscle NAD(P)H Two-Photon Fluorescence Microscopy In Vivo:...
Biophysical Journal;
March 1, 2005 ;
Rothstein, Emily C; Carroll, Stefanie; Combs, Christian A; Jobsis, Paul D; Balaban, Robert S;
787 words
......adenine dinucleotide (NAD(P)H) in murine skeletal muscle in vivo. NAD(P)H fluorescence emission...complexity, of using NAD(P)H TPEFM in skeletal muscle to characterize the topology and metabolic...the use of TPEFM to evaluate murine skeletal muscle morphology and energetics using ...
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Skeletal muscle changes after hemiparetic stroke and potential beneficial...
Journal of Rehabilitation Research and Development;
January 1, 2008 ;
Hafer-Macko, Charlene E; Ryan, Alice S; Ivey, Frederick M; Macko, Richard F;
787 words
......structural and metabolic changes in skeletal muscle after stroke. Muscle alterations...insulin resistance and diabetes. Skeletal muscle is a major site for insulin-gluco...impaired insulin action in skeletal muscle. The health benefits of exercise...exercise may modify or ...
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Multiple regions of RyR1 mediate functional and structural interactions...
Biophysical Journal;
December 1, 2002 ;
Protasi, Feliciano; Paolini, Cecilia; Nakai, Junichi; Beam, Kurt G; Et al;
787 words
......Ca^sup 2+^ release units (CRUs). In skeletal muscle this interaction is bidirectional...charge movement restored in dysgenic skeletal muscle by injection of dihydropyridine receptor...isoforms in mature avian fast twitch skeletal muscle. J. Biol. Chem. 265:14187-14194. Avila...
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