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Article: Zinc transporter mRNA expression in the RWPE-1 human prostate epithelial cell line.(COMMUNICATIONS-GRADUATE)(Report)
- Article from:
- Proceedings of the North Dakota Academy of Science
- Article date:
- April 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 North Dakota Academy of Science. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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The prostate accumulates and stores the highest amount of zinc of all soft tissues within the body, yet during prostatic neoplasia, the zinc content of this organ consistently and persistently falls to much lower levels. There are specialized membrane bound transporters that help to regulate the zinc homeostasis of the prostate. These transporters have been categorized into two families: ZnT (SLC30) and Zip (SLC39). Many of these genes have been newly discovered and full function and physiological role is not yet completely known. The ZnT family is responsible for pumping zinc out of the cell or into intracellular vesicles, decreasing the intracellular levels of zinc. In ...