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Article: Expression of keratin 6a and keratin 16 in arsenite and cadmium transformed UROTsa cell lines is induced in vivo and is associated with squamous differentiation.(COMMUNICATIONS--GRADUATE)(Author abstract)(Report)(Brief article)
- Article from:
- Proceedings of the North Dakota Academy of Science
- Article date:
- April 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 North Dakota Academy of Science. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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This laboratory has previously demonstrated that cadmium ([Cd.sup.+2]) and arsenite ([As.sup.+3]) transformed UROtsa cells grown on serum-containing growth medium and the derived heterotransplants all overexpressed keratin 6a mRNA and protein compared to parental UROtsa cells grown in serumcontaining growth medium. Growth factor deletion and addition studies indicated that the level of keratin 6a expression was regulated by the presence of both insulin and epidermal growth factor. In contrast, growth factors had no effect on the elevated levels of keratin 6a expression found in transformed UROtsa cells. Subsequently, this laboratory generated independently, additional ...
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