Article: Identification of heterogeneity among soft tissue sarcomas by gene expression profiles from different tumors.(Research)

Authors: Keith M Skubitz (corresponding author) [1]; Stefan Pambuccian [2]; J Carlos Manivel [2]; Amy PN Skubitz [2]

Introduction

Soft tissue sarcomas (STS) exhibit heterogeneity in their clinical behavior, even within the same histological subtypes. This heterogeneity is an important problem in the treatment of patients with STS. Gene expression is felt to play a critical role in cell development and malignant transformation, and gene expression profiles are of potential use in the classification and diagnosis of malignancies [1, 2, 3]. Several recent studies have found distinctive gene expression patterns that can differentiate between histologic ...

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