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Article: Studies from National Institute of Biology reveal new findings on gene therapy.
- Article from:
- Health & Medicine Week
- Article date:
- May 19, 2008
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A report, 'Patterns of microcystin-LR induced alteration of the expression of genes involved in response to DNA damage and apoptosis,' is newly published data in
Toxicon
. According to a study from Ljubljana, Slovenia, "Microcystins (MCs) are hepatotoxic cyclic heptapeptides produced by freshwater cyanobacteria. They are inhibitors of serine/threonine protein phosphatases 1A and 2A and are involved in liver tumor promotion."
"Several recent studies indicated that MCs are genotoxic and may also act as tumor initiators. Based on our previous results showing that microcystin-LR (MCLR) induces DNA damage in HepG2 cells, we have now explored the effect of MCLR on the ...