Is there room in the market for a recombinant thrombin?

Drug Topics;  March 10, 2008 ;   Magill-Lewis, Jillene;   787 words ......explained. In fact, bovine thrombin is used in...recombinant thrombin (Recothrom) and partnered...compete with bovine thrombin, which has...events with bovine thrombin have been few...indicating bovine thrombin was direcdy...numbers than with bovine ...

Risk and clinical significance of developing antibodies induced by topical...

Archives of Pathology & Laboratory Medicine;  October 1, 1998 ;   Dorion, R Patrick; Hamati, Husam F; Landis, Beth; Frey, Carolin; Et al;   787 words ......development in patients exposed to topical bovine thrombin preparations. Design.-A prevalence...individuals previously exposed to topical bovine thrombin was done by screening using Western blot assay to detect antibodies against bovine thrombin preparations. Setting.-A large ...

DOCTOR ISSUES WARNING ON BLOOD CLOT AGENT

United Press International;  October 31, 2001 ;     511 words ......studies involving mice show the agent bovine thrombin potentially could cause an autoimmune...where the body attacks its own tissue. Bovine thrombin is an enzyme extracted from cow blood...procedures. The problem, Lawson said, is bovine thrombin is so effective and convenient, ...

Validation of a prion and virus purification process in the manufacture of...

Journal of Applied Research;  September 1, 2007 ;   Terrab, Abdel Pawlak, Dan;   787 words ......Northborough, MA) during manufacture of bovine thrombin. Methods: Purified bovine thrombin was challenged with a high-titer clarified...runs were performed on priors-spiked bovine thrombin samples and 2 filtration runs were performed...

ZymoGenetics Discusses Detailed Results From Successful Phase 3 Trial...

PR Newswire;  September 18, 2006 ;     787 words ......The trial compared rhThrombin to bovine thrombin. As announced on September 5th 2006...immunogenicity profile as compared to bovine thrombin. Both treatments were well tolerated...randomized to receive rhThrombin or bovine thrombin; approximately half or 205 patients...

ZymoGenetics Reports Positive Results From Pivotal Phase 3 Clinical Trial...

PR Newswire;  September 5, 2006 ;     787 words ......Treatment with rhThrombin and bovine thrombin resulted in comparable incidence...versus 22 for those treated with the bovine thrombin product (p < 0.0001). Of patients in the bovine thrombin group who had pre-existing antibodies...

FDA APPROVES ZYMOGENETICS' FIRST PRODUCT BIOTECH CREATES SYNTHETIC VERSION...

Seattle Post-Intelligencer (Seattle, WA);  January 18, 2008 ;   Tartakoff, Joseph;   612 words ......Administration approved its first product, Recothrom, which the company believes eventually...up 8.75 percent, or $1.05, at $13.05. Recothrom, which the company previously referred...cows, and ZymoGenetics believes that Recothrom can avoid complications that have been...

ZymoGenetics Inc. Analyst Meeting - Final

Fair Disclosure Wire;  December 14, 2006 ;     787 words ......trial, comparing human recombinant to bovine thrombin. Our efficacy data couldn't have been...phase II. And we confirmed that the bovine thrombin did have an immunogenicity issue with...patients who came in had antibodies of bovine thrombin. And as you'll see later, the black-b...

Market Gainer administers coverage on OMRIX Biopharmaceuticals, Inc.

M2 Presswire;  October 17, 2006 ;     787 words ......equivalence of topical human thrombin to bovine thrombin in terms of safety and efficacy. All...thrombin, the investigational product or bovine thrombin, the control. Approximately half...equivalence of topical human thrombin to bovine thrombin in terms of efficacy as determined...

ThermoGenesis Corp. Receives Notice of Allowance of Second Patent For...

PR Newswire;  December 19, 2001 ;     684 words ......outcomes after surgical exposure to bovine thrombin http://www.ncbi.nlm.nih.gov/entrez...Abstract Exposure of mice to topical bovine thrombin induces systemic autoimmunity http...studies report an initial exposure to bovine thrombin sets up an increased risk of adverse...

Fibrin sealant facilitates hemostasis in arteriovenous...

The American Surgeon;  August 1, 2002 ;   Schenk, Worthington G III; Goldthwaite, Charles A Jr; Burks, Sandra; Spotnitz, William D;   787 words ......comparator groups (four) of bovine thrombin (T) (Thrombogen, GenTrac Inc., Middleton, WI), pressure (P), bovine thrombin (Thrombogen, GenTrac Inc...gelatin sponges, and topical bovine thrombin, although useful, have not...

ZymoGenetics Inc. at JPMorgan 25th Annual Healthcare Conference - Final

Fair Disclosure Wire;  January 11, 2007 ;     787 words ......formulations of antibodies against bovine thrombin, or the contaminating bovine factor...sentence. Patients with antibodies to bovine thrombin preparations should not be re-exposed...things was recombinant thrombin versus bovine thrombin, randomized, double-blind, pivotal...

ZymoGenetics Highlights Development Programs at Analyst & Investor...

PR Newswire;  December 8, 2005 ;     787 words ......clinical trial comparing rhThrombin to bovine thrombin (the currently marketed product) in...associated with the currently marketed bovine thrombin product. Dr. Lawson is a faculty member...extensively studied the immunogenicity of bovine thrombin and the relationship to ...

ThermoGenesis and Medtronic Sign Thrombin Processing Device(TM) (TPD(TM))...

PR Newswire;  November 8, 2005 ;     555 words ......Currently, approximately $50 million/year of bovine thrombin is consumed worldwide in the production of...platelet gels in lieu of products that utilize bovine thrombin. Bovine thrombin has been reported to cause adverse reactions...

Omrix reports positive results in Phase III clinical trials: Omrix has...

Globes (Tel Aviv, Israel);  October 17, 2006 ;     223 words ......1:1 ratio to receive either human thrombin, the product being tested, or bovine thrombin, the control product. The results indicated that human and bovine thrombin test subjects achieved hemostasis within 10 minutes, 97.4 percent of the...