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Article: Penn Animal Study Suggests Inadequate Sleep May Exacerbate Cellular Aging in the Elderly; Cellular Response to Sleep Deprivation Is Impaired in Old Mice.
- Article from:
- AScribe Medicine News Service
- Article date:
- June 30, 2008
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Byline: University of Pennsylvania Health System
PHILADELPHIA, June 30 (AScribe Newswire) -- Researchers at the University of Pennsylvania School of Medicine have shown that the unfolded protein response, which is an adaptive response to stress induced by sleep deprivation, is impaired in the brains of old mice.
The findings suggest that inadequate sleep in the elderly, who normally experience sleep disturbances, could exacerbate an already-impaired protective response to protein misfolding that happens in aging cells. "Protein misfolding and aggregation is associated with many diseases like Alzheimer's and Parkinson's," notes first author Nirinjini ...