Hepatocellular carcinoma (HCC) is a common cancer that typically occurs in the setting of cirrhosis and chronic hepatitis virus infections. Hepatitis B and C account for approximately 80% of cases worldwide. HCC is currently the fifth most common malignancy in men and the eighth in women worldwide; its incidence is increasing dramatically in many parts of the world. Recognition of those at risk and early diagnosis by surveillance with imaging, with or without serologic testing, are extremely important. Many highly effective and even curative therapies are now available and include resection, liver transplantation, and local ablation. Appropriate application of these ...
<5 cm in diameter or up to three nodules with none><4.5 cm and a cumulative diameter not exceeding 8 cm would do as well as patients meeting the Milan criteria, though there is a suggestion that the rate of tumor recurrence may be greater (126). Onaca studied a group of more than 1200 patients transplanted for HCC and found that those with a single lesion [less than or equal to] 6 cm or two to four tumors with none>