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Article: Determinants of cluster size in large, population-based molecular epidemiology study of tuberculosis, Northern Malawi.(RESEARCH)
- Article from:
- Emerging Infectious Diseases
- Article date:
- July 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 U.S. National Center for Infectious Diseases. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Tuberculosis patients with identical strains of Mycobacterium tuberculosis are described as clustered. Cluster size may depend on patient or strain characteristics. In a 7-year population-based study of tuberculosis in Karonga District, Malawi, clusters were defined by using IS6110 restriction fragment length polymorphism, excluding patterns with
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Molecular techniques, in particular restriction fragment length polymorphism (RFLP) based on the IS 6110 insertion element, are used to define clusters of isolates of Mycobacterium tuberculosis with identical DNA fingerprints. Many studies have investigated risk factors for clustering, but relatively little is ...