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Article: Am J Clin Nutr: Pharmacokinetics of a single, large dose of cholecalciferol.(Reprint)(Brief article)
- Article from:
- Alternative Medicine Review
- Article date:
- June 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 Thorne Research Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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2008;87:688-691.
BACKGROUND: There is much interest in dosing vitamin D intermittently for patient convenience and long-term adherence. OBJECTIVE: The objective was to characterize the time course and response of 25-hydroxyvitamin D (calcidiol) to a large oral dose of cholecalciferol. DESIGN: One group (30 subjects) was supplemented with a single oral dose of 100,000 IU cholecalciferol. A second group (10 subjects) served as a control group to assess the seasonal change of calcidiol. Serum calcidiol concentrations were followed for 4 mo. The subjects were healthy with limited sun exposure (