Article: Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells.(Research article)(Brain-derived neurotrophic factor)

Authors: Lorena Donnici (equal contributor) [1,2]; Ettore Tiraboschi (equal contributor) [1,3]; Daniela Tardito [1]; Laura Musazzi [1]; Giorgio Racagni [1]; Maurizio Popoli (corresponding author) [1]

Background

Brain-derived neurotrophic factor (BDNF) has been implicated in both the pathophysiology and pharmacotherapy of depression [1, 2, 3]. It has been shown that BDNF expression and/or function is impaired in major depression or following stress paradigms, while it is up-regulated by physical exercise and antidepressants. However, different and sometimes conflicting findings have been reported [2], showing that antidepressants change total BDNF ...

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