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Article: Time-dependent biphasic modulation of human BDNF by antidepressants in neuroblastoma cells.(Research article)(Brain-derived neurotrophic factor)
- Article from:
- BMC Neuroscience
- Article date:
- July 5, 2008
- Author:
CopyrightCOPYRIGHT 2008 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Lorena Donnici (equal contributor) [1,2]; Ettore Tiraboschi (equal contributor) [1,3]; Daniela Tardito [1]; Laura Musazzi [1]; Giorgio Racagni [1]; Maurizio Popoli (corresponding author) [1]
Background
Brain-derived neurotrophic factor (BDNF) has been implicated in both the pathophysiology and pharmacotherapy of depression [1, 2, 3]. It has been shown that BDNF expression and/or function is impaired in major depression or following stress paradigms, while it is up-regulated by physical exercise and antidepressants. However, different and sometimes conflicting findings have been reported [2], showing that antidepressants change total BDNF ...
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