Newspaper article from our research archive:
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Genes set scene for metastasis.
- Article from:
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Nutrition Health Review
- Article date:
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June 22, 2006
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Copyright informationCOPYRIGHT 2006 Vegetus Publications. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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[ILLUSTRATION OMITTED]
Metastasis (spreading of cancer) is the cause of 90 percent of deaths from cancer, yet little is know about its underlying mechanisms. Biologists at the Memorial Sloan-Kettering Cancer Center in New York identified a set of genes expressed in human breast cancer cells that worked together to remodel the network of blood vessels at the site of the primary tumor. These genes also promote the spread of breast cancer to the lungs.
Using genetic and pharmacological approaches, Joan Massague, Ph.D., Chair of the Center's Cancer Biology and Genetics Program, showed how four genes facilitated the formation of new tumor blood vessels, the release of ...
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