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Successful treatment of rotavirus-induced diarrhoea in suckling mice with egg yolk immunoglobulin.(Report)
- Article from:
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Journal of Health Population and Nutrition
- Article date:
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December 1, 2007
- Author:
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Copyright informationCOPYRIGHT 2007 International Centre for Diarrhoeal Disease Research Bangladesh. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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ABSTRACT
The role of specific immunoglobulins at mucosal sites in imparting protection against disease, such as rotavirus-associated diarrhoea, is well-established. Oral immunoglobulin therapy with egg yolk-derived anti-rotavirus immunoglobulins has previously been shown to achieve moderate therapeutic effect in diarrhoea due to rotavirus in a clinical trial. Here, data on the therapeutic potential of the same immunoglobulin preparation in an infant mouse model of rotavirus-induced diarrhoea is presented. The use of an animal model has allowed therapy to be evaluated with higher doses of immunoglobulins and has suggested that an improved therapeutic effect can be achieved ...
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