Article: Lactogenic differentiation of HC11 cells is not accompanied by downregulation of AP-2 transcription factor genes.(Short Report)

Authors: Richard J äger (equal contributor) [1]; Leontios Pappas (equal contributor) [2]; Hubert Schorle (corresponding author) [1]

Background

During pregnancy the mammary epithelium matures in a complex developmental process which culminates in the generation of alveoli containing the milk-secreting epithelium. The lactogenic differentiation of the secretory epithelial cells is characterized by the synthesis of lactose and milk fat and by the expression of milk protein genes, such as beta-casein or whey acidic protein (WAP). The regulatory networks and transcription factors controlling these developmental processes are only ...

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