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Article: Campinas State University details research in erectile dysfunction.
- Article from:
- Biotech Week
- Article date:
- July 30, 2008
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"The 5-[2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyll-l-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one, sildenafil, is a cGMP-specific phosphodiesterase-5 (PDE5) inhibitor used for penile erectile dysfunction. In the search for more potent and selective PDE5 inhibitors, new sildenafil analogues (6a-v), characterized by the presence on the sulfonyl group in the 5' position of novel N-4-substituted piperazines or ethylenediamine moiety, were prepared by traditional and micro wave-assisted synthesis and tested in rabbit isolated aorta and corpus cavernosum," scientists in Campinas, Brazil report (see also Erectile Dysfunction).
"Similarly to ...