Article: Differential temporal profile of lowered blood glucose levels (3.5 to 6.5 mmol/l versus 5 to 8 mmol/l) in patients with severe traumatic brain injury.(Research)(Clinical report)

Authors: Regula Meier [1]; Markus B échir [1]; Silke Ludwig [1]; Jutta Sommerfeld [1]; Marius Keel [2]; Peter Steiger [1]; Reto Stocker [1]; John F Stover (corresponding author) [1]

Introduction

After severe traumatic brain injury (TBI), secondary brain damage related to activated local cascades as well as systemic influences can compromise regenerative and reparative processes, thereby increasing morbidity and mortality. Within this context, elevated blood glucose concentrations at admission and during intensive care exceeding 9.4 mmol/l (170 mg/dl) are associated with increased mortality [1, 2] and morbidity [3, 4, 5] compared with ...

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