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Highly pathogenic avian influenza virus (H5N1) in experimentally infected adult mute swans.

Adult, healthy mute swans were experimentally infected with highly pathogenic avian influenza virus A/Cygnus cygnus/Germany/R65/2006 subtype H5N1. Immunologically naive birds died, whereas animals with preexisting, naturally acquired avian influenza virus-specific antibodies became infected asymptomatically and shed virus. Adult mute swans are highly susceptible, excrete virus, and can be clinically protected by preexposure immunity.

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Since 2002, highly pathogenic avian influenza (HPAI) subtype H5N1 viruses have spread from endemically infected areas of Southeast Asia to Europe and Africa and infected poultry and wild birds. Especially in Europe, swans ...

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