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Article: Pediatric pneumonia death caused by community-acquired methicillin-resistant Staphylococcus aureus, Japan.(LETTERS)
- Article from:
- Emerging Infectious Diseases
- Article date:
- August 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 U.S. National Center for Infectious Diseases. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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To the Editor: Community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA), which carries genes for Panton-Valentine leukocidin (PVL), has become a major concern worldwide (1-3). CA-MRSA is mainly associated with skin and soft tissue infections in young, otherwise healthy, persons in the community (3) and also with life-threatening sepsis and community-acquired pneumonia (preceded by influenza) (1,3,4). The role of PVL in the pathogenesis of staphylococcal infections is controversial. Whereas Labandeira-Rey et al. (5) provided data that PVL, in combination with staphylococcal protein A, destroys respiratory tissue and bacteria-engulfing immune cells, Voyich ...