Article: New findings from Mental Health Research Institute of Victoria in the area of life sciences described.(Report)

A new study, 'Phencyclidine-induced locomotor hyperactivity is enhanced in mice after stereotaxic brain serotonin depletion,' is now available. "The aim of this study was to investigate the role of forebrain serotonin projections in behavioural models with relevance to schizophrenia. Mice received stereotaxic micro-injections of the serotonin neurotoxin 5,7-dihydroxytryptamine into the median raphe nucleus (MRN)," scientists in Parkville, Australia report (see also Life Sciences).

"Two weeks later, MRN-lesioned mice were hyperactive at baseline and showed enhanced locomotor hyperactivity induced by phencyclidine. In contrast, no lesion effect was observed on the ...

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