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Article: Researchers from Ivan Franko National University publish findings in life sciences.
- Article from:
- Life Science Weekly
- Article date:
- September 9, 2008
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New investigation results, 'Coordination of export and glycosylation of landomycins in Streptomyces cyanogenus S136,' are detailed in a study published in FEMS Microbiology Letters. According to recent research from Ukraine, "In Streptomyces cyanogenus S136 gene cluster for biosynthesis of polyglycosylated angucycline landomycin A (LaA), a divergently oriented gene pair for a TetR-family regulator (lanK) and an efflux protein (lanJ) is located, whose functions remained obscure. Overexpression and disruption studies showed that lanK and lanJ genes control LaA resistance."
"Also, a constitutive lanK overexpression led to predominant accumulation of LaA precursors ...