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Article: Studies from Nanjing Medical University yield new information about pharmacokinetics.
- Article from:
- Biotech Week
- Article date:
- September 3, 2008
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"A sensitive liquid chromatography-tandem-mass spectrometry method was developed and validated for the determination of perospirone in human plasma, using quetiapine as internal standard. Plasma samples were extracted from 1 mL of plasma using n-hexane," researchers in Nanjing, People's Republic of China report (see also Pharmacokinetics).
"Chromatographic separation was performed on an Agilent Zorbax SB C-18 column with a mobile phase of 5 mM ammonium acetate solution-methanol (12:88, v/v, adjusted to pH 3.8 with glacial acetic acid) at a flow rate of 0.2 mL min(-1). The chromatographic separation was achieved in less than 4.6 min. The linearity was established ...
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