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Article: Studies from University of Michigan, Comprehensive Cancer Center provide new data on graft-versus-host disease.
- Article from:
- Blood Weekly
- Article date:
- September 4, 2008
CopyrightCOPYRIGHT 2008 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Data detailed in 'Combined Th2 cytokine deficiency in donor T cells aggravates experimental acute graft-vs-host disease' have been presented. "The role of T helper (Th) 1 and Th2 polarization in acute graft-vs-host-disease (GVHD) is unclear. We investigated the role of Th2 cytokine secretion by utilizing donor T cells that cannot make interleukin (IL)-4, IL-5, IL-9, and IL-13 from quadruple cytokine-deficient (Quad-KO) animals in a well-characterized BALB/c-- >C57BL/6 model of allogeneic bone marrow transplantation," scientists writing in the journal Experimental Hematology report (see also Graft-Versus-Host Disease).
"B6 recipients of BALB/c Quad-KO T cells ...