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Article: Scientists at University of Cambridge publish research in nanotechnology.
- Article from:
- Journal of Engineering
- Article date:
- September 24, 2008
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"We have previously shown that a 'weak' fibronectin type III (fnIII) domain can be engineered to have enhanced mechanical strength by replacing the hydrophobic core with the core of a homologous 'strong' fnIII domain. Here we show that engineering the core is a robust method for manipulating the mechanical strength of this class of proteins," scientists writing in the journal Nanotechnology report.
"We performed an experiment that is the reverse of one described earlier. The hydrophobic core of a 'weak' domain (FNfn10) was grafted into a 'strong' fnIII domain, TNfn3. This newly engineered protein, TNoFNc, is indeed much less mechanically resistant than TNfn3," ...
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... ... knockdown," wrote J. Hirst and colleagues, University of Cambridge, Cambridge Institute for Medical Research (see also ... additional information, contact J. Hirst, University of Cambridge, Cambridge Institute for Medical Research ...
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