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Article: Studies from Mental Health Research Institute of Victoria further understanding of pharmacology.(Report)
- Article from:
- Biotech Week
- Article date:
- September 24, 2008
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Current study results from the report, 'Role of serotonin-1A receptors in the action of antipsychotic drugs: comparison of prepulse inhibition studies in mice and rats and relevance for human pharmacology,' have been published. "This study aimed to explore strain and species differences in the involvement of 5-HT1A receptors in the action of antipsychotic drugs, using prepulse inhibition (PPI), a model of sensory processing which is deficient in schizophrenia patients. We used automated startle boxes to compare the effect of the 5-HT1A receptor agonist, ([+ or -])-8-hydroxy-dipropyl-amino-tetralin (8-OH-DPAT), on PPI in three mouse strains," scientists writing in the ...