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Article: Research from S.K. Knudsen et al has provided new information about biochemistry.
- Article from:
- Chemicals & Chemistry
- Article date:
- September 19, 2008
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According to a study from Aalborg, Denmark, "Autotransporters constitute the biggest group of secreted proteins in Gram-negative bacteria and contain a membrane-bound beta-domain and a passenger domain secreted to the extracellular environment via an unusually long N-terminal sequence. Several passenger domains are known to be glycosylated by cytosolic glycosyl transferases, promoting bacterial attachment to mammalian cells."
"In the present study we describe the effect of glycosylation on the extracellular passenger domain of the Escherichia coli auntotransporter Ag43 alpha, which induces frizzy colony morphology and cell settling. We identify 16 glycosylation ...