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Article: Gene expression changes linked to antimicrobial resistance, oxidative stress, iron depletion and retained motility are observed when Burkholderia cenocepacia grows in cystic fibrosis sputum.(Research article)
- Article from:
- BMC Infectious Diseases
- Article date:
- September 19, 2008
- Author:
CopyrightCOPYRIGHT 2008 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Pavel Drevinek [1]; Matthew TG Holden [2]; Zhaoping Ge [3]; Andrew M Jones [4]; Ian Ketchell [5]; Ryan T Gill [6]; Eshwar Mahenthiralingam (corresponding author) [1]
Background
Cystic fibrosis (CF) is the most common hereditary disease in Caucasian population affecting one in every 2,500 - 4,500 newborns. People with CF lack a functional chloride transporter normally present in epithelial cell membranes which results in multiple organ system impairment. The respiratory tract is one of the most profoundly affected systems where the defect in ion transport causes production of highly viscous mucus. The resulting ineffective mucocilliary ...
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Article: Pandoraea apista can cause chronic lung infection in CF ...
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... ... capable of causing chronic lung infection in cystic fibrosis (CF) patients." "It is most likely that this strain of P. apista was ... therefore be considered a new and sometimes important pathogen for CF patients," the researchers concluded. "Cohort isolation prevented ...
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