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Article: Direct contact of platelets and their released products exert different effects on human dendritic cell maturation.(Research article)
- Article from:
- BMC Immunology
- Article date:
- September 25, 2008
- Author:
CopyrightCOPYRIGHT 2008 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Hind Hamzeh-Cognasse [1]; Fabrice Cognasse [1,2]; Sabine Palle [3]; Patricia Chavarin [2]; Thomas Olivier [3]; Olivier Del
ézay [1]; Bruno Pozzetto [1]; Olivier Garraud (corresponding author) [1,2]
Background
Dendritic cells (DCs) are sentinels of the immune system, involved in innate and adaptive immunity, the role of which is to guard the periphery for signs of foreign invasion. Recognition of pathogens by immature DCs is mediated by a set of receptors that includes Toll-like receptors (TLRs) [1], Fc-receptors [2], and C-type lectins [3]. Upon a "danger signal", immature DCs develop into mature immunostimulatory DCs. ...
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