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Article: NF-kappaB mediates the survival of human bronchial epithelial cells exposed to cigarette smoke extract.(Research)(nuclear factor-kappa B)
- Article from:
- Respiratory Research
- Article date:
- September 23, 2008
- Author:
CopyrightCOPYRIGHT 2008 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Xiangde Liu [1]; Shinsaku Togo [2]; Mona Al-Mugotir [1]; Huijung Kim [3]; QiuHong Fang [4]; Tetsu Kobayashi [5]; XingQi Wang [1]; Lijun Mao [6]; Peter Bitterman [7]; Stephen Rennard (corresponding author) [1]
Background
Cigarette smoke is the major preventable risk factor for a variety of diseases including lung cancer and emphysema. However, the mechanisms by which cigarette smoke causes these varying diseases are not yet fully understood. One key mechanism is believed to be the ability of cigarette smoke to damage cellular DNA leading to the accumulation of somatic cell mutations, which is believed to contribute to the development of ...
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