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Article: Scientists at University of Minnesota, Department of Pharmacology target dwarfism.
- Article from:
- Biotech Week
- Article date:
- October 15, 2008
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Researchers detail in 'Reduced ability of C-type natriuretic peptide (CNP) to activate natriuretic peptide receptor B (NPR-B) causes dwarfism in lbab -/- mice,' new data in dwarfism. According to a study from the United States, "C-type natriuretic peptide (CNP) stimulates endochondrial ossification by activating the transmembrane guanylyl cyclase, natriuretic peptide receptor-B (NPR-B). Recently, a spontaneous autosomal recessive mutation that causes severe dwarfism in mice was identified."
"The mutant, called long bone abnormality (lbab), contains a single point mutation that converts an arginine to a glycine in a conserved coding region of the CNP gene, but how ...