Article: Data on life sciences described by researchers at University of Zimbabwe, Department of Biochemistry.

Researchers detail in 'Lysosomal trapping of amodiaquine: impact on transport across intestinal epithelia models,' new data in life sciences. "The lipophilic weak base amodiaquine is an antimalarial drug that has been in use for over 40 years. Little is known of amodiaquine's mechanism of transport across membranes," investigators in Mount Pleasant, Zimbabwe report (see also Life Sciences).

"Transport experiments of amodiaquine in Caco-2 cells showed a low recovery of 30% and rapid disappearance from the apical chamber. Compounds structurally similar to amodiaquine, and those affecting non-specific binding of amodiaquine or the pH of the system, were tested to ...

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