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Article: Researchers at University of Illinois release new data on enzyme research.(Report)
- Article from:
- OBGYN & Reproduction Week
- Article date:
- October 13, 2008
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"Estrogen exposure through early menarche, late menopause, and hormone replacement therapy increases the risk factor for hormone-dependent cancers. Although the molecular mechanisms are not completely established, DNA damage by quinione electrophilic reactive intermediates, derived from estrogen oxidative metabolism, is strongly implicated," investigators in the United States report (see also Enzyme Research).
"A current hypothesis has 4-hydroxyestrone-o-quinone (4-OQE) acting as the proximal estrogen carcinogen, forming depurinating DNA adducts via Michael addition. One aspect of this hypothesis posits a key role for NAD(P)H-dependent quinone oxidoreductase ...