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Article: Study results from M. Fedi and colleagues in the area of frontal lobe epilepsy published.(Report)
- Article from:
- Biotech Week
- Article date:
- October 22, 2008
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"Mutations of the neuronal nicotinic acetylcholine (nACh) receptor identified in patients with autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE) lead to increased sensitivity to ACh. As activation of presynaptic nicotinic receptors augments the release of dopamine in the striatum and the prefrontal regions, we tested the hypothesis that that the alpha 4-Ser248Phe mutation affects dopaminergic transmission," scientists writing in the journal Neurology report (see also Frontal Lobe Epilepsy).
"We measured D-1 receptor binding using [C-11]-SCH23390 and PET in 12 subjects with the alpha 4-Ser248Phe mutation (3 men, mean age 41 +/- 16 years) and 19 controls ...