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Article: Apple extracts prevent stomach damage due to aspirin.(IN THE NEWS)(Brief article)
- Article from:
- Life Extension
- Article date:
- September 1, 2008
- Author:
CopyrightCOPYRIGHT 2008 LE Publications, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Apple polyphenol extracts protected rats from stomach damage due to aspirin in an Italian study. * Aspirin, a nonsteroidal anti-inflammatory drug (NSAID), can cause gastrointestinal problems such as bleeding and ulcers, even at the low doses given for cardiovascular health.
[ILLUSTRATION OMITTED]
In this study, 45 rats underwent pretreatment with apple polyphenol extracts or no pretreatment, followed by administration of aspirin to produce stomach injury. Apple polyphenol pretreatment reduced microscopic and macroscopic stomach injury by 40-45% compared with untreated rats and prevented increases in cyclo-oxygenase-2 and other damaging substances. ...