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Article: Acai (euterpe oleracea mart.) polyphenolics in their glycoside and aglycone forms induce apoptosis of HL-60 leukemia cells.(Berries)(human leukemia)(Brief article)(Clinical report)
- Article from:
- Life Extension
- Article date:
- September 1, 2008
CopyrightCOPYRIGHT 2008 LE Publications, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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The effects of acai polyphenolics on the antiproliferation and induction of apoptosis in HL-60 human leukemia cells were investigated. Interactions between anthocyanins and non-anthocyanin-polyphenolics in both their glycosidic and their aglycone forms were also investigated to determine additive or nonadditive responses. Polyphenolic fractions at 0.17-10.7 microM were found to reduce cell proliferation from 56 to 86% likely due to caspase-3 activation (apoptosis). Anthocyanin and polyphenolic fractions were nonadditive in their contribution to the cell antiproliferation activity. At equimolar concentrations, the glycosidic forms of phenolic acids and flavonoids induced a ...