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Article: Blood pressures, heart rate and locomotor activity during salt loading and angiotensin II infusion in protease-activated receptor 2 (PAR.sub.2 ) knockout mice.(Research article)(Report)
- Article from:
- BMC Physiology
- Article date:
- October 21, 2008
- Author:
CopyrightCOPYRIGHT 2008 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: John J McGuire (corresponding author) [1]; Bruce N Van Vliet [1]; Sarah J Halfyard [1]
Background
Protease-activated receptor 2 (PAR
2
), a 7 transmembrane domain G protein coupled receptor, has been found to be activated endogenously by specific serine proteases [1, 2]. Supposedly, rather than by the binding of any known soluble ligands in the circulation, serine proteases released by endothelial cells and other cells during inflammation and/or injury initiates PAR
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