Article: Blood pressures, heart rate and locomotor activity during salt loading and angiotensin II infusion in protease-activated receptor 2 (PAR.sub.2 ) knockout mice.(Research article)(Report)

Authors: John J McGuire (corresponding author) [1]; Bruce N Van Vliet [1]; Sarah J Halfyard [1]

Background

Protease-activated receptor 2 (PAR 2 ), a 7 transmembrane domain G protein coupled receptor, has been found to be activated endogenously by specific serine proteases [1, 2]. Supposedly, rather than by the binding of any known soluble ligands in the circulation, serine proteases released by endothelial cells and other cells during inflammation and/or injury initiates PAR

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