Article: Elicitation of protective immune responses using a bivalent H5N1 VLP vaccine.(Research)(Clinical report)

Authors: Corey J Crevar [1]; Ted M Ross (corresponding author) [1,2]

Introduction

Since re-emerging in 2003, avian influenza viruses of the H5N1 subtype have spread from Southeast Asia across central Asia and the Middle East into Europe and Africa by infecting wild birds and poultry. New influenza viruses and genotypes are emerging each year and are leading to significant genetic variation among H5N1 viruses [1]. Currently, 10 clades of H5N1 isolates have been identified in birds. Recent human isolates have clustered into two distinct clades, clade 1 and clade 2, with clade 2 further being divided into subclades 2.1, 2.2, and 2.3. Although H5N1 remains an avian virus, not ...

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