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Article: Research from University of London, Imperial College reveals new findings on lupus.
- Article from:
- Biotech Week
- Article date:
- October 29, 2008
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"C-reactive protein (CRP) is a heritable acute-phase plasma protein also expressed at low, basal, levels in healthy individuals. Elevated basal CRP has been associated with increased cardiovascular risk, while CRP dysregulation may be a feature of systemic lupus erythematosus (SLE)," scientists in London, the United Kingdom report (see also Lupus).
"In this cohort of 496 Caucasian SLE families we estimated basal CRP heritability, h(2) = 27.7%. We typed a dense map of CRP single nucleotide polymorphisms (SNPs) and found that seven were associated with basal CRP using both a regression approach and an orthogonal family-based test (P = 0.001-0.011), as were ...