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Article: New chromatography study findings recently were reported by M. Guerrini and co-researchers.(Report)
- Article from:
- Blood Weekly
- Article date:
- October 30, 2008
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Current study results from the report, 'Antithrombin-binding octasaccharides and role of extensions of the active pentasaccharide sequence in the specificity and strength of interaction. Evidence for very high affinity induced by an unusual glucuronic acid residue,' have been published. According to recent research published in the Journal of Biological Chemistry, "The antithrombotic activity of low molecular weight heparins (LMWHs) is largely associated with the antithrombin (AT)-binding pentasaccharide sequence AGA(*)IA (GlcN(NAc/NS,6S)-GlcA-GlcN(NS,3,6S)-IdoUA(2S)-GlcN(NS,6S)). The location of the AGA(*)IA sequences along the LMWH chains is also expected to influence ...