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Article: Studies from University of Connecticut, Center for Vascular Biology add new findings in the area of Wilms' tumor genetics.(Report)
- Article from:
- Angiogenesis Weekly
- Article date:
- November 14, 2008
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New research, 'Induction of antiproliferative connective tissue growth factor expression in wilms' tumor cells by sphingosine-1-phosphate receptor 2,' is the subject of a report. According to a study from the United States, "Connective tissue growth factor (CTGF), a member of the CCN family of secreted matricellular proteins, regulates fibrosis, angiogenesis, cell proliferation, apoptosis, tumor growth, and metastasis. However, the role of CTGF and its regulation mechanism in Wilms' tumor remains largely unknown."
"We found that the bioactive lipid sphingosine-1-phosphate (S1P) induced CTGF expression in a concentration-and time-dependent manner in a Wilms' ...
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