|
|
Article: New findings from A.A. Soderholm and co-authors in the area of chemical modeling published.
- Article from:
- Chemicals & Chemistry
- Article date:
- November 14, 2008
CopyrightCOPYRIGHT 2008 NewsRX. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
|
According to a study from Espoo, Finland, "We have identified and profiled a set of androgen receptor (AR) binding compounds representing two nonsteroidal scaffolds from a public chemical database supplied by Asinex with virtual screening procedure incorporating our recently published 3D QSAR model of AR ligands. The diphenyl- and phenylpyridine-based compounds act as antagonists in wild-type AR in CV1 cells and also retain this antagonistic character in CV1 cells expressing T877A mutant receptor."
"This mutation is frequently associated with prostate cancer. Two of the compounds repress the androgen-dependent cell growth of LNCaP prostate cancer cells expressing ...
Related newspaper, magazine, and journal articles:
|
|
Article: SODERHOLM-4160764.(Business)
Daily Herald (Arlington Heights, IL);
June 14, 2009 ;
445 words
...Catherine J. Soderholm of Arlington Heights A memorial Mass for Catherine Soderholm (nee McCafferty), 49, will be celebrated ... 2009, at her home in Arlington Heights. Mrs. Soderholm was employed by Sargeant & ...
|
|