Article: Comparative analysis of the time-dependent functional and molecular changes in spinal cord degeneration induced by the G93A SOD1 gene mutation and by mechanical compression.(Research article)(Clinical report)

Authors: Andrea Malaspina (corresponding author) [1]; Natasa Jokic [1]; Wenlong L Huang [1]; John V Priestley [1]

Background

Spinal cord degeneration in humans resulting from a mechanical injury or developing in the context of a neurodegenerative disorder causes a variable degree of neurological disability. Functional recovery after a mechanical insult to the spinal cord depends on the force and site of impact, on the duration of uninterrupted compression and possibly, on a genetically-determined ability of the nervous tissue to activate repair mechanisms. Similarly, non-traumatic neurodegenerative disorders affecting the spinal cord present a wide range of clinical ...

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