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Article: Clue to Lou Gehrig's disease emerges. (amyotrophic lateral sclerosis)
- Article from:
- Science News
- Article date:
- November 30, 1996
- Author:
CopyrightCOPYRIGHT 1996 Science Service, Inc. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Amyotrophic lateral sclerosis (ALS), the neurodegenerative disease that killed baseball legend Lou Gehrig and slays about 1 in 1,000 people, has largely defied explanation. An inherited enzyme defect identified in 1993 accounts for only a few percent of the cases.
Now, researchers have evidence suggesting that many ALS cases, perhaps the majority, result from abnormal genetic instructions that leave the brain and spinal cord unable to sponge up glutamate, a potentially destructive amino acid. The resulting glutamate buildup presumably causes the disease's cardinal feature-the death of the nerve cells, or neurons, that control the body's muscles.
Neurons ...