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Article: The Kv2.1 K.sup.+ .sup.channel targets to the axon initial segment of hippocampal and cortical neurons in culture and in situ.(Research article)(Report)
- Article from:
- BMC Neuroscience
- Article date:
- November 13, 2008
- Author:
CopyrightCOPYRIGHT 2008 BioMed Central Ltd. This material is published under license from the publisher through the Gale Group, Farmington Hills, Michigan. All inquiries regarding rights should be directed to the Gale Group. (Hide copyright information)
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Authors: Patrick D Sarmiere [1,2]; Cecile M Weigle [1]; Michael M Tamkun (corresponding author) [1]
Background
Voltage-gated ion channels are often highly localized in electrically excitable cells such as nerve and muscle. As originally noted by Trimmer and colleagues [1], the Kv2.1 delayed rectifier is expressed primarily in the somatic region of hippocampal neurons where it is found in cell surface clusters that can co-localize with ryanodine receptors and SR-like subsurface cisterns [2, 3]. Interestingly, these clusters also co-localize with cholinergic synapses in spinal motor neurons [4]. Kv2.1 represents the predominant delayed rectifier current ...
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