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Article: Scientists at University of Gottingen publish new data on amyotrophic lateral sclerosis genetics.
- Article from:
- Biotech Week
- Article date:
- December 17, 2008
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New investigation results, 'Low Ca2+ buffering in hypoglossal motoneurons of mutant SOD1 (G93A) mice,' are detailed in a study published in Neuroscience Letters. "Mutations in the Cu/Zn superoxide dismutase (SOD1) gene are associated with amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disorder characterized by a selective degeneration of brainstem and spinal motoneurons. The pathomechanism of degeneration is still incompletely understood, but includes a disruption in cellular Ca2+ homeostasis," scientists in Germany report (see also Amyotrophic Lateral Sclerosis Genetics).
"Here we report a quantitative microfluorometric analysis of the Ca2+ ...