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Article: Research in the area of inflammation reported from Y.D. Wang and colleagues.
- Article from:
- Biotech Week
- Article date:
- December 24, 2008
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According to recent research from the United States, "The farnesoid X receptor (FXR) is a nuclear receptor that plays key roles in hepatoprotection by maintaining the homeostasis of liver metabolism. FXR null mice display strong hepatic inflammation and develop spontaneous liver tumors."
"In this report, we demonstrate that FXR is a negative modulator of nuclear factor kappa B (NF-kappa B)-mediated hepatic inflammation. Activation of FXR by its agonist ligands inhibited the expression of inflammatory mediators in response to NF-kappa B activation in both HepG2 cells and primary hepatocytes cultured in vitro. In vivo, compared with wild-type controls, FXR-/- mice ...